A memorial service will take place at Heaton Park synagogue later to commemorate the victims and survivors.
Chief Rabbi Ephraim Mirvis and Mayor of Manchester Bev Craig will be among those attending.
For those affected by the attack, the physical and emotional consequences are still being felt.
Bernard Agyemang, a security guard, is still recovering from the severe injuries he suffered when al-Shamie drove a car into him before trying to get into the synagogue with a knife.
Agyemang said he continued to struggle with the memories of the attack.
“The events of that day will stay with me forever,” he said.
“I still live with the physical injuries and the emotional trauma caused by the attack, and there are days when the memories feel just as vivid as they did a year ago.”
The 44-year-old from south Manchester suffered multiple fractures, including to his right leg and collarbone, as well as a suspected brain injury.
He continues to experience physical pain, cognitive difficulties and psychological trauma including PTSD.
Agyemang condemned the “hatred and violence that caused so much suffering” last year.
“Anniversaries like this are a reminder of everything that was taken from our community,” he said. “But they are also an opportunity to come together, support one another and remember those we lost.
“My thoughts are with the families of Melvin and Adrian.
“No words can ease the pain of losing loved ones in such terrible circumstances.”